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Article Publish Status: FREE
Abstract Title:

Assessing the Anti-inflammatory Effects of Bacopa-Derived Bioactive Compounds Using Network Pharmacology andStudies.

Abstract Source:

ACS Omega. 2022 Nov 8 ;7(44):40344-40354. Epub 2022 Oct 30. PMID: 36385888

Abstract Author(s):

Rajendran Jeyasri, Pandiyan Muthuramalingam, Sivakumar Adarshan, Hyunsuk Shin, Manikandan Ramesh

Article Affiliation:

Rajendran Jeyasri

Abstract:

is reported as a potent Indian medicinal plant that possesses numerous pharmacological activities due to the presence of various bioactive compounds. These pharmacological activities were used in the ancient medicine system to cure inflammatory conditions. Bacopa has the ability to reduce acute pain and inflammation by inhibiting the enzyme cyclo-oxygenase-2 () and reducing-arbitrated prostanoid mediators. Moreover, the anti-inflammatory property may also be associated with the neuroprotective activity of Bacopa. Considering this importance, the current pilot study focused on the anti-inflammatory potential of various phytocompounds of bacopa and their interaction with inflammation responsible genes such as,,,,, andthrough pharmacology analysis of its systems. Docking results revealed that, quercetin (QR) showed significant binding energies with inflammatory genes. Hence, we selected QR as a potential phytocompound for furtherexperiments. This existing study aimed to evaluate the efficacy of QR as a potent anti-inflammatory compound against lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Theanalysis concludes that QR effectively reduces the production of nitric oxide (NO) in LPS-induced RAW264.7 cells and downregulates the expression ofandgenes due to the inhibitory potential of QR on LPS-stimulated NO production.

Study Type : In Vitro Study

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