Article Publish Status: FREE
Abstract Title:

Assessment of bisphenol A levels in preschool children-Results of a human biomonitoring study in Ankara, Turkey

Abstract Source:

J Clin Res Pediatr Endocrinol. 2019 Sep 2. Epub 2019 Sep 2. PMID: 31475509

Abstract Author(s):

İsmet Çok, İkidağ Özlem T., Dilek Battal, Ayça Aktaş

Article Affiliation:

İsmet Çok


Objective: There is general concern regarding environmental chemical exposures and the impact it may have on human health, which is particularly important for vulnerable populations such as infants and children in critical periods of development. Bisphenol A (BPA) is an endocrine disrupting chemical used worldwide over the last 30 years in many consumer products that play an important role in our daily life. The aim of this study was to evaluate the exposure of Turkish preschool children to BPA.

Methods: This study conducted a preliminary investigation of BPA in urine collected from 3-6 year old children (mean age: 4.50±1.26) living in Ankara. For this purpose, after spot urine samples were taken from preschool children (n=125; Males n= 70, Females n=55), free BPA, β-D-glucuronide (BPA-GLU) and total BPA were determined using high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS).

Results: Total BPA was detected in 76.8% of children from Ankara city, with concentrations ranging from0.05). The estimated daily BPA intake in this study is substantially lower than the European Food Safety Authority derived tolerable Daily intake (TDI) of 4µg/kg BW/day.

Conclusion: This study is an important contribution to the limited information about childhood exposure to BPA.

Study Type : Human Study
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