Association between fine particulate matter and coronary heart disease. - GreenMedInfo Summary

Several studies have reported an association between residential surrounding particulate matter with an aerodynamic diameter≤2.5 μm (PM) and coronary heart disease (CHD). However, the underlying biological mechanism remains unclear. To fill this research gap, this study enrolled a residentially stable sample of 942 patients with CHD and 1723 controls. PMconcentration was obtained from satellite-based annual global PMestimates for the period 1998-2019. MicroRNA microarray and pathway analysis of target genes was performed to elucidate the potential biological mechanism by which PMincreases CHD risk. The results showed that individuals exposed to high PMconcentrations had higher risks of CHD than those exposed to low PMconcentrations (odds ratio = 1.22, 95% confidence interval: 1.00, 1.47 per 10 μg/mincrease in PM). Systolic blood pressure mediated 6.6% of the association between PMand CHD. PMand miR-4726-5p had an interaction effect on CHD development. Bioinformatic analysis demonstrated that miR-4726-5p may affect the occurrence of CHD by regulating the function of RhoA. Therefore, individuals in areas with high PMexposure and relative miR-4726-5p expression have a higher risk of CHD than their counterparts because of the interaction effect of PMand miR-4726-5p on blood pressure.