Abstract Title:

Association of Cycling with Risk of All-Cause and Cardiovascular Disease Mortality: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies.

Abstract Source:

Sports Med. 2021 Mar 28. Epub 2021 Mar 28. PMID: 33774807

Abstract Author(s):

Yang Zhao, Fulan Hu, Yifei Feng, Xingjin Yang, Yang Li, Chunmei Guo, Quanman Li, Gang Tian, Ranran Qie, Minghui Han, Shengbing Huang, Xiaoyan Wu, Yanyan Zhang, Yuying Wu, Dechen Liu, Dongdong Zhang, Cheng Cheng, Ming Zhang, Yongli Yang, Xuezhong Shi, Jie Lu, Dongsheng Hu

Article Affiliation:

Yang Zhao


BACKGROUND: Cycling has been suggested to be related to risk of all-cause and cardiovascular disease (CVD) mortality. However, a quantitative comprehensive assessment of the dose-response association of cycling with risk of all-cause and CVD mortality has not been reported. We performed a meta-analysis of cohort studies assessing the risk of all-cause and CVD mortality with cycling.

METHODS: PubMed and Embase databases were searched for relevant articles published up to December 13, 2019. Random-effects models were used to estimate the summary relative risk (RR) of all-cause and CVD mortality with cycling. Restricted cubic splines were used to evaluate the dose-response association.

RESULTS: We included 9 articles (17 studies) with 478,847 participants and 27,860 cases (22,415 from all-cause mortality and 5445 from CVD mortality) in the meta-analysis. Risk of all-cause mortality was reduced 23% with the highest versus lowest cycling level [RR 0.77, 95% confidence interval (CI) 0.67-0.88], and CVD mortality was reduced 24% (RR 0.76, 95% CI 0.65-0.89). We found a linear association between cycling and all-cause mortality (P = 0.208); the risk was reduced by 9% (RR 0.91, 95% CI 0.86-0.96) with each five metabolic equivalent of task (MET)-h/week increase in cycling. We found an approximately U-shaped association between cycling and CVD mortality (P = 0.034), with the lowest risk at approximately 15 MET-h/week of cycling.

CONCLUSIONS: Our findings based on quantitative data suggest that any level of cycling is better than none for all-cause mortality. However, for CVD mortality, one must choose an appropriate level of cycling, with an approximate optimum of 15 MET-h/week (equal to 130 min/week at 6.8 MET).

Study Type : Meta Analysis, Review

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