Abstract Title:

Astaxanthin ameliorates lung fibrosis in vivo and in vitro by preventing transdifferentiation, inhibiting proliferation, and promoting apoptosis of activated cells.

Abstract Source:

Food Chem Toxicol. 2013 Jun ;56:450-8. Epub 2013 Mar 14. PMID: 23500768

Abstract Author(s):

Meirong Wang, Jinjin Zhang, Xiaodong Song, Wenbo Liu, Lixia Zhang, Xiuwen Wang, Changjun Lv

Article Affiliation:

Meirong Wang


Astaxanthin, a member of the carotenoid family, is the only known ketocarotenoid transported into the brain by transcytosis through the blood-brain barrier. However, whether astaxanthin has antifibrotic functions is unknown. In this study, we investigated the effects of astaxanthin on transforming growth factorβ1-mediated and bleomycin-induced pulmonary fibrosis in vitro and in vivo. The results showed that astaxanthin significantly improved the structure of the alveoli and alleviated collagen deposition in vivo. Compared with the control group, the astaxanthin-treated groups exhibited downregulated protein expressions of α-smooth muscle actin, vimentin, hydroxyproline, and B cell lymphoma/leukemia-2 as well as upregulated protein expressions of E-cadherin and p53 in vitro and in vivo. Astaxanthin also inhibited the proliferation of activated A549 and MRC-5 cells at median inhibitory concentrations of 40 and 30 μM, respectively. In conclusion, astaxanthin could relieve the symptoms and halt the progression of pulmonary fibrosis, partly by preventing transdifferentiation, inhibiting proliferation, and promoting apoptosis of activated cells.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anti-Fibrotic : CK(924) : AC(463)

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