Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation. - GreenMedInfo Summary
Abstract Title:
Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction.
Abstract Source:
Am J Cardiol. 2004 Nov 15 ;94(10):1306-10. PMID: 15541254
Article Affiliation:
Heart Failure Institute, Department of Medicine, Advocate Christ Medical Center, University of Illinois/Christ Cardiovascular Disease Fellowship Program, Oak Lawn, Illinois 60453, USA. marc.silver@advocatehealth.com
Abstract:
This study evaluated left ventricular diastolic function with Doppler echocardiography before and after statin therapy. Statin therapy worsened diastolic parameters in most patients; coenzyme Q(10) supplementation in patients with worsening diastolic function with statin therapy improved parameters of diastolic function.
Article Published Date : Nov 15, 2004
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(1858) : AC(315)
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Heart Failure : CK(1240) : AC(183), Hypertension : CK(6384) : AC(950), Statin-Induced Pathologies : CK(1848) : AC(368)
Pharmacological Actions : Anticholesteremic Agents : CK(3078) : AC(530), Antioxidants : CK(21528) : AC(8856)
Problem Substances : Atorvastatin : CK(551) : AC(106), Statin Drugs : CK(4587) : AC(553)
Adverse Pharmacological Actions : Cardiotoxic : CK(1000) : AC(164)
