Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation. - GreenMedInfo Summary

Abstract Title:

Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction.

Abstract Source:

Am J Cardiol. 2004 Nov 15 ;94(10):1306-10. PMID: 15541254

Abstract Author(s):

Marc A Silver, Peter H Langsjoen, Szabolcs Szabo, Harish Patil, Allan Zelinger

Article Affiliation:

Heart Failure Institute, Department of Medicine, Advocate Christ Medical Center, University of Illinois/Christ Cardiovascular Disease Fellowship Program, Oak Lawn, Illinois 60453, USA. [email protected]

Abstract:

This study evaluated left ventricular diastolic function with Doppler echocardiography before and after statin therapy. Statin therapy worsened diastolic parameters in most patients; coenzyme Q(10) supplementation in patients with worsening diastolic function with statin therapy improved parameters of diastolic function.

Article Published Date : Nov 15, 2004

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10 : CK(2361) : AC(413)

Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Heart Failure : CK(1929) : AC(337), Hypertension : CK(9188) : AC(1367), Statin-Induced Pathologies : CK(1852) : AC(370)

Pharmacological Actions : Anticholesteremic Agents : CK(4097) : AC(671), Antioxidants : CK(34736) : AC(14570)

Problem Substances : Atorvastatin : CK(567) : AC(110), Statin Drugs : CK(4608) : AC(562)

Adverse Pharmacological Actions : Cardiotoxic : CK(1303) : AC(237)