Abstract Title:

Autoimmune hemolytic anemia accompanied by reactivation of an Epstein-Barr virus infection with suppressed CTL response to EBV-infected cells in an elderly man.

Abstract Source:

Intern Med. 2010;49(4):325-9. Epub 2010 Feb 15. PMID: 20154439

Abstract Author(s):

Ayako Arai, Ken-Ichi Imadome, Shigeyoshi Fujiwara, Osamu Miura

Article Affiliation:

Department of Hematology, Tokyo Medical and Dental University.


An 88-year-old man with autoimmune hemolytic anemia (AIHA) who had been treated with low dose prednisolone developed a sudden worsening of his anemia accompanied by reactivation of Epstein-Barr virus (EBV). We established EBV-infected spontaneous lymphoblastoid cell lines (LCL), performed an enzyme-linked immunosorbent spot assay, and confirmed a significantly suppressed EBV-specific cytotoxic T-cell (CTL) response to the LCL. EBV reactivation might have been brought about by suppressed CTL activity which could have been due to low dose PSL administration or aging. Since the EBV-DNA titer decreased as AIHA improved, we concluded that EBV might have played a role in the development of anemia.

Study Type : Human Study

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Sayer Ji
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