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Article Publish Status: FREE
Abstract Title:

Bevacizumab Regulates Cancer Cell Migration by Activation of STAT3.

Abstract Source:

Asian Pac J Cancer Prev. 2015 ;16(15):6501-6. PMID: 26434865

Abstract Author(s):

Huan-Huan Wu, Shuai Zhang, Huan Bian, Xiao-Xu Li, Lin Wang, Yin-Fei Pu, Yi-Xiang Wang, Chuan-Bin Guo

Article Affiliation:

Huan-Huan Wu

Abstract:

There are numerous clinical cases indicating that long-term use of bevacizumab may increase the invasiveness of tumors. However, to date, little is known about underlying molecular mechanisms. Therefore, the purpose of our study was to investigate effects of bevacizumab in four cancer cells lines (WSU-HN6, CAL27, Tca83, and HeLa). It was found to promote migration and invasion in the WSU-HN6 and Tca83 cases, while exerting inhibitory effects in CAL27 and HeLa cells. The signal transducer and activator of transcription (STAT) 3 inhibitors niclosamide and S3I-201 inhibited the STAT3 signal pathway, which is activated by bevacizumab. These inhibitors also substantially blocked bevacizumab-induced migration of WSU-HN6 and Tca83 cells. Bevacizumab upregulated interleukin (IL)-6 and phosphorylated (p)-STAT3 expression time-dependently. Therefore, we propose that bevacizumab has differential effects on the migration of different cancer cell lines and promotes migration via the IL-6/STAT3 signaling pathway.

Study Type : In Vitro Study

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