Article Publish Status: FREE
Abstract Title:

Avocado Consumption, Abdominal Adiposity, and Oral Glucose Tolerance Among Persons with Overweight and Obesity.

Abstract Source:

J Nutr. 2021 Sep 4 ;151(9):2513-2521. PMID: 34191028

Abstract Author(s):

Naiman A Khan, Caitlyn G Edwards, Sharon V Thompson, Bridget A Hannon, Sarah K Burke, Anne D M Walk, Richard W A Mackenzie, Ginger E Reeser, Barbara H Fiese, Nicholas A Burd, Hannah D Holscher

Article Affiliation:

Naiman A Khan


BACKGROUND: Although intake of Hass avocado has been cross-sectionally linked to lower abdominal obesity, knowledge of the effects of avocado consumption on abdominal adiposity and glycemic outcomes remains limited.

OBJECTIVE: The effects of avocado consumption on abdominal adiposity, insulin resistance, oral-glucose-tolerance test (OGTT), and estimatedβ-cell function were evaluated.

METHODS: A total of 105 adults aged 25-45 y (61% female) with BMI≥25 kg/m2 were randomly assigned to an intervention (N = 53) that received a daily meal with 1 fresh Hass avocado or a control (N = 52) that received an isocaloric meal with similar ingredients without avocado for 12 wk. DXA was used to assess the primary outcomes of abdominal adiposity [visceral adipose tissue (VAT), subcutaneous abdominal adipose tissue (SAAT), and the ratio of VAT to SAAT (VS Ratio)]. Fasted glucose and insulin were used to assess the primary outcomes of insulin resistance (HOMA-IR), and insulin sensitivity (Matsuda index) andβ-cell function (Insulinogenic index) were estimated using an OGTT. Changes between groups were compared using an ANCOVA. Secondary analyses were conducted based on sex.

RESULTS: The control group exhibited a greater reduction in SAAT [-54.5 ±155.8 g (control) compared with 17.4 ±155.1 g (treatment), P = 0.017] and increase in VS Ratio [0.007 ±0.047 (control) compared with -0.011 ±0.044 (treatment), P = 0.024]. Among females, the treatment group exhibited a greater reduction in VAT [1.6 ±89.8 g (control) compared with -32.9 ±81.6 g (treatment), P = 0.021] and VS Ratio [0.01 ±0.05 (control) compared with -0.01 ±0.03 (treatment), P = 0.001]. Among males, there was no significant difference between groups in changes in abdominal adiposity or glycemic outcomes.

CONCLUSIONS: Daily consumption of 1 fresh Hass avocado changed abdominal adiposity distribution among females but did not facilitate improvements in peripheral insulin sensitivity orβ-cell function among adults with overweight and obesity.This study was registered at clinicaltrials.gov as NCT02740439.

Study Type : Human Study

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