Abstract Title:

Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice.

Abstract Source:

Food Res Int. 2019 May ;119:751-760. Epub 2018 Oct 22. PMID: 30884712

Abstract Author(s):

Brena Ramos Athaydes, Gisele Maziero Alves, Arícia Leone Evangelista Monteiro de Assis, João Victor Dutra Gomes, Ricardo Pereira Rodrigues, Bianca Prandi Campagnaro, Breno Valentim Nogueira, Dâmaris Silveira, Ricardo Machado Kuster, Thiago Melo Costa Pereira, Rodrigo Rezende Kitagawa, Rita de Cássia Ribeiro Gonçalves

Article Affiliation:

Brena Ramos Athaydes


The long-term use of anti-inflammatory drugs is the most common cause of gastric ulcer disease, one of the major gastrointestinal disorders affecting people worldwide. Persea americana Mill. (avocado) seed is a by-product generally discarded as waste, but can be used to treat gastric disorder due to its anti-inflammatory, antioxidant and antimicrobial activities. The aim of the present study was to evaluate the potential protective effects of the ethyl acetate fraction of avocado seeds (SEAP) extracts against indomethacin-induced gastric ulcer in mice. It was found that SEAP were effective in mitigating oxidative stress through a decrease on the oxidized products levels (reduction of 90% in lipid peroxidation in plasma) and increasing superoxide dismutase enzyme (SOD) activity (4.25-fold increase compared to the indomethacin group), also preventing the rise in ulcer and lesions areas (92% of protection) and histological changes induced by indomethacin. Chemical analysis using mass spectrometry by (-)-ESI-FT-ICR MS revealed the presence of (-)-epicatechin and (+)-catechin, confirmed by HPLC-DAD, and other important phenolic compounds in avocado seeds, such as caffeoylquinic acid, flavonoids, phenylpropanoids and tannins, substances that promote inhibition of pathways involved in gastric ulcer formation. Thus, avocado seeds extract may be a suitable natural source for the prevention and treatment of gastric ulcer.

Study Type : Animal Study

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