Article Publish Status: FREE
Abstract Title:

Azelaic Acid Exerts Antileukemic Activity in Acute Myeloid Leukemia.

Abstract Source:

Front Pharmacol. 2017 ;8:359. Epub 2017 Jun 12. PMID: 28659796

Abstract Author(s):

Yunbao Pan, Dong Liu, Yongchang Wei, Dan Su, Chenyang Lu, Yanchao Hu, Fuling Zhou

Article Affiliation:

Yunbao Pan


Acute myeloid leukemia (AML) is an acute leukemia common in most adults; its prevalence intensifies with age. The overall survival of AML is very poor because of therapeutic resistance. Azelaic acid (AZA) is non-toxic, non-teratogenic, and non-mutagenic and its antitumor effect on various tumor cells is well established; Nonetheless, its therapeutic effects in AML cells are largely unknown. In this study, it was shown that AZA significantly inhibits the cell viability and induces apoptosis in AML cells in a dose-dependent manner. Additionally, AZA suppressed the expression of phosphorylated Akt, Jab1 and Trx, and this suppression was enhanced by treatment with Jab1 siRNA. Furthermore, AZA sensitized AML cells to Ara-c chemotherapy. The suppressive effect of AZA on tumor growth was examined in vivo by subcutaneously inoculated AML cells in a tumor model using nude mice. These findings indicate that AZA is useful as an effective ingredient in antineoplastic activity.

Study Type : Animal Study, In Vitro Study

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