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Abstract Title:

in Patients with Parkinson's Disease: A Pilot Study.

Abstract Source:

J Med Food. 2023 Feb ;26(2):114-119. PMID: 36800346

Abstract Author(s):

Andreia Fuentes Dos Santos, Marília Moraes Queiroz Souza, Eduarda Carolina Amaral, Edilson Rodrigues Albuquerque, Durcelina Schiavoni Bortoloti, Arquimedes Gasparotto Junior, Emerson Luiz Botelho Lourenço, Evellyn Claudia Wietzikoski Lovato, Francislaine Aparecida Dos Reis Lívero

Article Affiliation:

Andreia Fuentes Dos Santos

Abstract:

(L.) Wettst. could be of interest in the control of symptoms of Parkinson's disease, but clinical evidence of its efficacy is lacking. This clinical trial assessed the effects of an extract ofon parameters that are related to Parkinson's diseases. Twenty volunteers with Parkinson's disease were recruited for a primary, interventional, controlled, parallel, double-blind clinical study. The volunteers were assigned to treatment with either a commercialextract (225 or 450 mg/day) or placebo. The Parkinson's Disease Quality-of-Life (PDQL) questionnaire was applied, and motor activity was assessed before treatment and 30, 60, and 90 days after treatment with theextract or placebo. Characteristics such as age, body weight, and height were also collected. No differences in parkinsonian and systemic symptoms, emotional function, or social function were observed between. The delta percent (Δ%) showed time-dependent improvements in emotional function withtreatment at the daily dose of 450 mg. A strong correlation was found between quality of life and motor outcomes at baseline and 30 days of treatment with, and a moderate correlation for 60 and 90 days of treatment withwhen compared with baseline time. A moderate correlation was found between motor outcomes and Hoehn and Yahr stages at baseline. Our results suggest thatextract can improve emotional function in Parkinson's disease patients, but further clinical trials are needed to confirm this possibility.

Study Type : Human Study

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