Abstract Title:

Modulation of NF-κB and FOXOs by baicalein attenuates the radiation-induced inflammatory process in mouse kidney.

Abstract Source:

Free Radic Res. 2011 May;45(5):507-17. Epub 2011 Feb 1. PMID: 21284490

Abstract Author(s):

Eun Kyeong Lee, Ji Min Kim, Jehun Choi, Kyung Jin Jung, Dae Hyun Kim, Sang Woon Chung, Young Mi Ha, Byung Pal Yu, Hae Young Chung

Article Affiliation:

College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.


Abstract The bioactive flavonoid baicalein has been shown to have radioprotective activity, although the molecular mechanism is poorly understood in vivo. C57BL/6 mice were irradiated with X-rays (15 Gy) with and without baicalein treatment (5 mg/kg/day). Irradiation groups showed an increase of NF-κB-mediated inflammatory factors with oxidative damage and showed inactivation of FOXO and its target genes, catalase and SOD. However, baicalein suppressed radiation-induced inflammatory response by negatively regulating NF-κB and up-regulating FOXO activation and catalase and SOD activities. Furthermore, baicalein inhibited radiation-induced phosphorylation of MAPKs and Akt, which are the upstream kinases of NF-κB and FOXOs. Based on these findings, it is concluded that baicalein has a radioprotective effect against NF-κB-mediated inflammatory response through MAPKs and the Akt pathway,which is accompanied by the protective effects on FOXO and its target genes, catalase and SOD. Thus, these findings provide new insights into the molecular mechanism underlying the radioprotective role of baicalein in mice.

Study Type : Animal Study

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