Abstract Title:

Baicalein 5,6,7-trimethyl ether, a flavonoid derivative, stimulates fatty acid beta-oxidation in skin fibroblasts of X-linked adrenoleukodystrophy.

Abstract Source:

FEBS Lett. 2005 Jan 17;579(2):409-14. PMID: 15642351

Abstract Author(s):

Masashi Morita, Ikuko Takahashi, Mariko Kanai, Fumito Okafuji, Makoto Iwashima, Toshimitsu Hayashi, Shiro Watanabe, Tomohito Hamazaki, Nobuyuki Shimozawa, Yasuyuki Suzuki, Hirokazu Furuya, Takeshi Yamada, Tsuneo Imanaka


The purpose of the present study is to identify bioactive compounds with potential for X-linked adrenoleukodystrophy (X-ALD) pharmacological therapy. Various plant natural products including flavonoids were tested for their ability to ameliorate the abnormality of very long chain fatty acid (VLCFA) metabolism in cultured skin-fibroblasts from X-ALD patients. Of the compounds tested, baicalein 5,6,7-trimethyl ether (baicalein-tri-Me) was found to significantly stimulate the VLCFA beta-oxidation activity. Furthermore, the incorporation of [1-(14)C]lignoceric acid into cholesteryl esters was markedly reduced towards the normal level and the VLCFA (C24:0 and C26:0) content was decreased. These results make baicalein-tri-Me a candidate for the therapeutic compound for X-ALD.


Study Type : In Vitro Study

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Sayer Ji
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