Article Publish Status: FREE
Abstract Title:

Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress.

Abstract Source:

Biomol Ther (Seoul). 2016 Nov 1 ;24(6):616-622. PMID: 27257012

Abstract Author(s):

Min Chang Oh, Mei Jing Piao, Pattage Madushan Dilhara Jayatissa Fernando, Xia Han, Susara Ruwan Kumara Madduma Hewage, Jeong Eon Park, Mi Sung Ko, Uhee Jung, In Gyu Kim, Jin Won Hyun

Article Affiliation:

Min Chang Oh


Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) radiation in a human keratinocyte cell line (HaCaT). Baicalein absorbed light within the wavelength range of UVB. In addition, baicalein decreased the level of intracellular reactive oxygen species (ROS) in response to UVB radiation. Baicalein protected cells against UVB radiation-induced DNA breaks, 8-isoprostane generation and protein modification in HaCaT cells. Furthermore, baicalein suppressed the apoptotic cell death by UVB radiation. These findings suggest that baicalein protected HaCaT cells against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging ROS.

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