Abstract Title:

In vitro synergism of fluconazole and baicalein against clinical isolates of Candida albicans resistant to fluconazole.

Abstract Source:

Biol Pharm Bull. 2008 Dec;31(12):2234-6. PMID: 19043205

Abstract Author(s):

Shan Huang, Ying Ying Cao, Bao Di Dai, Xuan Rong Sun, Zhen Yu Zhu, Yong Bing Cao, Yan Wang, Ping Hui Gao, Yuan Ying Jiang

Article Affiliation:

School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.


In vitro interaction of fluconazole and baicalein (BE) was investigated against 30 fluconazole-resistant clinical isolates of Candida albicans. Synergistic activities were determined using the checkerboard microdilution assay based on the fractional inhibitory concentration indices. Organisms were also tested against the 2 drugs singly and in combination using time-kill methods. Both fluconazole and BE showed weak antifungal activity when tested alone. However, the combination of fluconazole and BE showed strong antifungal activity against most of the fluconazole-resistant isolates tested. The findings of time-kill curves confirmed the interaction. Yeast cells grown in the presence of BE exhibited a reduced extrusion of Rhodamine 6G, which indicates the inhibition of efflux pumps by BE. This novel synergism of fluconazole and BE that can overcome drug-resistance in yeast may prove useful in combined treatment of fungal infections.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antifungal Agents : CK(494) : AC(306)
Additional Keywords : Drug: Fluconazole : CK(4) : AC(0)

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