Abstract Title:

Short-term feeding of baicalin inhibits age-associated NF-kappaB activation.

Abstract Source:

Mech Ageing Dev. 2006 Sep;127(9):719-25. Epub 2006 Jun 12. PMID: 16766019

Abstract Author(s):

Dae Hyun Kim, Hyung Keun Kim, Seongjoon Park, Ji Young Kim, Yani Zou, Ki Ho Cho, Young Suk Kim, Dong Hyun Kim, Byung Pal Yu, Jae Sue Choi, Hae Young Chung


Baicalin is a flavonoid isolated from Scutellaria baicalensis and is known to affect multiple biological functions, including the inhibition of aldose reductase, HIV infection, and nitric oxide producing activity. Oxidative stress is considered a major cause of aging and various age-related diseases, and among the key cellular components exquisitely sensitive to oxidative stress is the transcription factor, nuclear factor-kappaB (NF-kappaB). In the present study, we attempted to elucidate the mechanisms underlying the suppression of age-related NF-kappaB activation by baicalin in kidney tissue from old rats. Results showed NF-kappaB activation and the upregulation of NF-kappaB targeting genes, hemoxygenase-1, inducible nitric oxide synthase (iNOS), and COX-2 with age. In contrast, the increased expression of these NF-kappaB targeting genes was effectively inhibited by baicalin. Baicalin was shown to inhibit the NF-kappaB cascade via three signal transduction pathways, NIK/IKK, extracellular signal-regulated kinase (ERK), and p38 mitogen-activated protein kinase (MAPK). Our results clearly indicated the anti-oxidative effects of baicalin on age-related redox imbalance. Thus, the significance of the current study is the new information revealing the anti-oxidative properties of baicalin and the role it plays in the regulation of age-related alterations.

Study Type : Animal Study

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Sayer Ji
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