Article Publish Status: FREE
Abstract Title:

Essential Oil of Ocimum basilicum L. and (-)-Linalool Blocks the Excitability of Rat Sciatic Nerve.

Abstract Source:

Evid Based Complement Alternat Med. 2016 ;2016:9012605. Epub 2016 Jun 30. PMID: 27446227

Abstract Author(s):

Antonio Medeiros Venancio, Francisco Walber Ferreira-da-Silva, Kerly Shamyra da Silva-Alves, Hugo de Carvalho Pimentel, Matheus Macêdo Lima, Michele Fraga de Santana, Péricles Barreto Alves, Givanildo Batista da Silva, José Henrique Leal-Cardoso, Murilo Marchioro

Article Affiliation:

Antonio Medeiros Venancio


The racemate linalool and its levogyrus enantiomer [(-)-LIN] are present in many essential oils and possess several pharmacological activities, such as antinociceptive and anti-inflammatory. In this work, the effects of essential oil obtained from the cultivation of the Ocimum basilicum L. (EOOb) derived from Germplasm Bank rich in (-)-LIN content in the excitability of peripheral nervous system were studied. We used rat sciatic nerve to investigate the EOOb and (-)-LIN effects on neuron excitability and the extracellular recording technique was used to register the compound action potential (CAP). EOOb and (-)-LIN blocked the CAP in a concentration-dependent way and these effects were reversible after washout. EOOb blocked positive amplitude of 1st and 2nd CAP components with IC50 of 0.38± 0.2 and 0.17 ± 0.0 mg/mL, respectively. For (-)-LIN, these values were 0.23 ± 0.0 and 0.13 ± 0.0 mg/mL. Both components reduced the conduction velocity of CAP and the 2nd component seems to be more affected than the 1st component. In conclusion EOOb and (-)-LIN inhibited the excitability of peripheral nervous system in a similar way and potency, revealing that the effects of EOOb on excitability are due to the presence of (-)-LIN in the essential oil.

Study Type : Animal Study
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