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Abstract Title:

Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization.

Abstract Source:

Front Pharmacol. 2021 ;12:644886. Epub 2021 Apr 30. PMID: 33995055

Abstract Author(s):

Hong-Xia Yang, Jia-Huan Sun, Ting-Ting Yao, Yuan Li, Geng-Rui Xu, Chuang Zhang, Xing-Chao Liu, Wei-Wei Zhou, Qiu-Hang Song, Yue Zhang, Ai-Ying Li

Article Affiliation:

Hong-Xia Yang

Abstract:

Myocardial fibrosis is closely related to high morbidity and mortality. In Inner Mongolia,(Michx.) J.M.Gillett () is a kind of tea used to prevent cardiovascular diseases. Bellidifolin (BEL) is an active xanthone molecule fromthat protects against myocardial damage. However, the effects and mechanisms of BEL on myocardial fibrosis have not been reported., BEL dampened isoprenaline (ISO)-induced cardiac structure disturbance and collagen deposition.BEL inhibited transforming growth factor (TGF)-β1-induced cardiac fibroblast (CF) proliferation., BEL decreased the expression ofα-smooth muscle actin (α-SMA), collagen Ⅰ and Ⅲ, and inhibited TGF-β1/Smads signaling. Additionally, BEL impeded p38 activation and NR4A1 (an endogenous inhibitor for pro-fibrogenic activities of TGF-β1) phosphorylation and inactivation. In CFs, inhibition of p38 by SB203580 inhibited the phosphorylation of NR4A1 and did not limit Smad3 phosphorylation, and blocking TGF-β signaling by LY2157299 and SB203580 could decrease the expression of α-SMA, collagen I and III. Overall, both cell and animal studies provide a potential role for BEL against myocardial fibrosis by inhibiting the proliferation and phenotypic transformation of CFs. These inhibitory effects mightbe related to regulating TGF-β1/Smads pathway and p38 signaling and preventing NR4A1 cytoplasmic localization.

Study Type : Animal Study, In Vitro Study

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