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Article Publish Status: FREE
Abstract Title:

Beneficial Effects ofDefatted Seed Meal on Visceral Pain and Intestinal Damage Resulting from Colitis in Rats.

Abstract Source:

Foods. 2022 Feb 17 ;11(4). Epub 2022 Feb 17. PMID: 35206057

Abstract Author(s):

Elena Lucarini, Laura Micheli, Eleonora Pagnotta, Roberto Matteo, Carmen Parisio, Alessandra Toti, Valentina Ferrara, Clara Ciampi, Alma Martelli, Lara Testai, Vincenzo Calderone, Michele Savino, Mario Russo, Nicola Pecchioni, Carla Ghelardini, Lorenzo Di Cesare Mannelli

Article Affiliation:

Elena Lucarini

Abstract:

Most therapies used in patients affected by inflammatory bowel diseases are ineffective in preventing the development of chronic visceral hypersensitivity, mainly due to inflammation-induced enteric neuroplasticity. Glucosinolates, secondary metabolites mainly ofwith anti-inflammatory and neuroprotective properties, are effective in treating both neuropathic and arthritis pain through HS release and Kv7 potassium channel activation. The aim of this work was to investigate the protective and anti-hyperalgesic efficacy of a defatted seed meal fromMill. (Brassicaceae), rich in glucosinolates, in a rat model of colitis induced by 2,4-dinitrobenzene sulfonic acid (DNBS). The mechanisms of action were also investigated. Visceral pain was assessed by measuring the abdominal response to colorectal distension. Fifteen days after colitis induction, the acute administration ofdefatted seed meal (0.1-1 g kgp.o.) dose-dependently relieved pain. This effect was hampered by co-administering an HS scavenger or a selective Kv7 blocker. Administering(1 g kg) for 14 days, starting after DNBS injection, contributed to counteracting visceral pain persistence in the post-inflammatory phase of colitis by promoting colon healing from the damage and reducing enteric gliosis.defatted seed meal might be employed as a nutraceutical tool for supporting abdominal pain relief in patients.

Study Type : Animal Study

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