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Article Publish Status: FREE
Abstract Title:

The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of.

Abstract Source:

Int J Mol Sci. 2020 Sep 7 ;21(18). Epub 2020 Sep 7. PMID: 32906784

Abstract Author(s):

Dong Wook Choi, Sang Woo Cho, Seok-Geun Lee, Cheol Yong Choi

Article Affiliation:

Dong Wook Choi

Abstract:

The root bark ofhas long been appreciated as an antiphlogistic, diuretic and expectorant drug in Chinese herbal medicine, albeit with barely known targets and mechanisms of action. In the 1970s, the development of analytic chemistry allowed for the discovery of morusin as one of 7 different isoprene flavonoid derivatives in the root bark of. However, the remarkable antioxidant capacity of morusin with the unexpected potential for health benefits over the other flavonoid derivatives has recently sparked scientific interest in the biochemical identification of target proteins and signaling pathways and further clinical relevance. In this review, we discuss recent advances in the understanding of the functional roles of morusin in multiple biological processes such as inflammation, apoptosis, metabolism and autophagy. We also highlight recent in vivo and in vitro evidence on the clinical potential of morusin treatment for multiple human pathologies including inflammatory diseases, neurological disorders, diabetes, cancer and the underlying mechanisms.

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