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Article Publish Status: FREE
Abstract Title:

Beneficial Shifts in Gut Microbiota byR0011 andR0052 in Alcoholic Hepatitis.

Abstract Source:

Microorganisms. 2022 Jul 21 ;10(7). Epub 2022 Jul 21. PMID: 35889193

Abstract Author(s):

Haripriya Gupta, Sung Hun Kim, Seul Ki Kim, Sang Hak Han, Hak Cheol Kwon, Ki Tae Suk

Article Affiliation:

Haripriya Gupta

Abstract:

Gut microbiota performs indispensable functions in the pathophysiology of alcoholic hepatitis (AH). We investigated the effects ofR0011 andfor gut microbial restoration toward eubiosis in patients with AH. A multicenter, double-blind, and randomized trial was conducted. Probiotics (n = 44) and placebo (n = 45) groups received, during 7 days,R0011/R0052 at 120 mg/day and placebo. All patients were hospitalized to ensure abstinence. Liver function, lipopolysaccharide level, and stool analysis were evaluated in patients before and after 7 days of treatment. At baseline, the dominant bacteria were Gram-negative in both groups which decreased after the probiotics treatment and exhibited a significant reduction in lipopolysaccharide level (< 0.001). The probiotics ameliorated the Child-Pugh scores (< 0.001). Furthermore, the probiotics group showed a decline in the levels of alanine aminotransferase and gamma-glutamyltranspeptidase (< 0.05). The probiotics changed the gut microbial composition at various taxonomical levels. The proportion of(147%) was increased after 7 days of probiotics supplementation while(30%) and(0%) were decreased. Administration ofR0011 andR0052 conceivably associated with restoration of gut microbiome in AH patients and improved AH by modulating the gut-liver axis.

Study Type : Human Study

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