Abstract Title:

Benefit of passion fruit as an anti-ulcerogenic diet: Scientific evidence by in-vitro and in-silico H+/K+ATPase inhibitory activity assessment.

Abstract Source:

Curr Comput Aided Drug Des. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654519

Abstract Author(s):

Vineeth Ajaya Kumar, Mridula Ramkumar, S K Kanthlal

Article Affiliation:

Vineeth Ajaya Kumar


BACKGROUND: H+/K+ ATPase a well-known protein present in the parietal cells is a better target for the prevention and treatment of the disease. Flavonoids have been reported to elicit beneficial effect by inhibiting the proton pump as well as by antioxidant mechanism.

METHODOLOGY: In this study chloroform fraction of hydro-alcoholic extract of passion fruit was screened for proton pump inhibitory assay using goat parietal cell. Report and conclusion: The flavonoid rich fruit possess a good radical scavenging activity against DPPH. 10.41µg/mL is sufficient to inhibit the 50% activity of the ATPase enzyme of goat parietal cell. A synergistic activity was also achieved by the fruit with sub-effective doses of lansoprazole. Fenton's oxidation was also protected by the fruit induced by H2O2. Including the in-silico findings, the beneficial potency of passion fruit in curing ulcer has been evidenced and perhaps the fruit can be a good dietary supplement for the prevention and its associated complications.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & receive The Dark Side of Wheat Ebook

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.