Abstract Title:

Activity related to the carcinogenicity of plastic additives in the benzophenone group.

Abstract Source:

J UOEH. 2006 Jun 1;28(2):143-56. PMID: 16780223

Abstract Author(s):

Daisuke Nakajima, Shin Asada, Shiho Kageyama, Takashi Yamamoto, Hidetoshi Kuramochi, Noriho Tanaka, Ken Takeda, Sumio Goto

Article Affiliation:

Research Centerfor Environmental Risk, National Institutefor Environmental Studies, Onogawa, Tsukuba, Ibaraki 305-8506, Japan.


This study examines the activities relating to the carcinogenicity of six types of benzophenone derivatives (benzophenone, 2-hydroxy-4-octyloxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone and 2,2'-dihydroxy-4,4'-dimethoxybenzophenone) currently used in plastic products as additives to serve as ultraviolet absorbing agents. The evaluation of the initiation activity used a light absorption umu-test, a luminescent umu-test and the Ames test. The promotion activity was examined by a Bhas assay, a method that uses Bhas 42 cells for the formation of transformation foci. The luminescent umu-test indicated positive initiation activity of 2-hydroxy-4-methoxybenzophenone, and pseudo-positive activity of 2,4-dihydroxybenzophenone and 2,2'-dihydroxy-4-methoxybenzophenone. In the Ames test, 2-hydroxy-4-octyloxybenzophenone showed pseudo-positive initiation activity. Conversely, 2,4-dihydroxybenzophenone indicated weak promotion activity at 10 microg/ml concentration.

Study Type : In Vitro Study
Additional Links
Problem Substances : Oxybenzone : CK(29) : AC(9)
Adverse Pharmacological Actions : Carcinogenic : CK(1048) : AC(155)

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