Abstract Title:

Berberine attenuates olanzapine induced-metabolic syndrome.

Abstract Source:

J Pak Med Assoc. 2019 Aug ;69(Suppl 3)(8):S88-S92. PMID: 31603885

Abstract Author(s):

Marwa Salih Al-Naimi, Huda Abdulbaki Rasheed, Hayder M Al-Kuraishy, Ali I Al-Gareeb

Article Affiliation:

Marwa Salih Al-Naimi


Objective: To elucidate the protective effect of berberine on olanzapine induced-metabolic syndrome.

Methods: This prospective experimental study involved thirty Sprague-Dawley male rats which were divided into three groups. Group A (n=10): Rats treated with distilled water, Group B (n=10): Rats treated with olanzapine, Group C (n=10): Rats treated with olanzapine plus berberine. The duration of the study was 8 weeks, baseline and follow up data were evaluated. Fasting blood glucose(FBG) total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL), Low density lipoprotein (LDL), atherogenic index of plasma (AI), fasting serum insulin level, insulin resistance,β- cell function and insulin sensitivity were evaluated.SPSS 20.

Results: Olanzepine led to significant deterioration in gluco-metabolic profile compared with control P<0.01. Olanzapine plus berberine improved body weight, FBG, FSI, HOMA-IR and QUICKI compared with olanzapine P=0.0001.

Conclusions: Berberine attenuates olanzapine induced-metabolic via amelioration of gluco-lipid disturbances.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Hypolipidemic : CK(5358) : AC(1221)
Problem Substances : Olanzapine : CK(10) : AC(1)

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