Article Publish Status: FREE
Abstract Title:

Berries as a Treatment for Obesity-Induced Inflammation: Evidence from Preclinical Models.

Abstract Source:

Nutrients. 2021 Jan 23 ;13(2). Epub 2021 Jan 23. PMID: 33498671

Abstract Author(s):

Hannah Land Lail, Rafaela G Feresin, Dominique Hicks, Blakely Stone, Emily Price, Desiree Wanders

Article Affiliation:

Hannah Land Lail


Inflammation that accompanies obesity is associated with the infiltration of metabolically active tissues by inflammatory immune cells. This propagates a chronic low-grade inflammation associated with increased signaling of common inflammatory pathways such as NF-κB and Toll-like receptor 4 (TLR4). Obesity-associated inflammation is linked to an increased risk of chronic diseases, including type 2 diabetes, cardiovascular disease, and cancer. Preclinical rodent and cell culture studies provide robust evidence that berries and their bioactive components havebeneficial effects not only on inflammation, but also on biomarkers of many of these chronic diseases. Berries contain an abundance of bioactive compounds that have been shown to inhibit inflammation and to reduce reactive oxygen species. Therefore, berries represent an intriguing possibility for the treatment of obesity-induced inflammation and associated comorbidities. This review summarizes the anti-inflammatory properties of blackberries, blueberries, strawberries, and raspberries. This review highlights the anti-inflammatory mechanisms of berries and their bioactive components that havebeen elucidated through the use of preclinical models. The primary mechanisms mediating the anti-inflammatory effects of berries include a reduction in NF-κB signaling that may be secondary to reduced oxidative stress, a down-regulation of TLR4 signaling, and an increase in Nrf2.

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Sayer Ji
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