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Abstract Title:

Anti-inflammatory potential ofβ-cryptoxanthin against LPS-induced inflammation in mouse Sertoli cells.

Abstract Source:

Reprod Toxicol. 2016 04 ;60:148-55. Epub 2015 Dec 10. PMID: 26686910

Abstract Author(s):

Xiao-Ran Liu, Yue-Ying Wang, Xin-Gang Dan, Ashok Kumar, Ting-Zhu Ye, Yao-Yao Yu, Li-Guo Yang

Article Affiliation:

Xiao-Ran Liu

Abstract:

β-cryptoxanthin (CX), a major carotenoid pigment, can inhibit inflammatory gene expression in mice with nonalcoholic steatohepatitis. In the present study, we examined the anti-inflammatory effects of CX on lipopolysaccharide (LPS)-induced inflammation in mouse primary Sertoli cells and the possible molecular mechanisms behind its effects. The results showed that CX significantly inhibited LPS-induced decreases in cell viability and in the percentage of apoptotic cells. Moreover, CX inhibited the LPS-induced up-regulation of tumor necrosis factor α (TNF-α), interleukin-10 (IL-10), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in Sertoli cells. In addition, CX significantly limited the LPS-induced down-regulation of AR, HSF2, CREB, FSHR, INHBB and ABP in Sertoli cells. Western blot analysis showed that CX significantly suppressed NF-κB (p65) activation as well as MAPK phosphorylation. All the results suggested that CX suppressed inflammation, possibly associated with the NF-κB activation and MAPK of phosphorylation. Thus, CX may possess therapeutic potential against inflammation-related diseases.

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