Article Publish Status: FREE
Abstract Title:

The protective effects ofβ-cryptoxanthin on inflammatory bone resorption in a mouse experimental model of periodontitis.

Abstract Source:

Biosci Biotechnol Biochem. 2013 ;77(4):860-2. PMID: 23615426

Abstract Author(s):

Chiho Matsumoto, Noriyuki Ashida, Satoshi Yokoyama, Tsukasa Tominari, Michiko Hirata, Kazunori Ogawa, Minoru Sugiura, Masamichi Yano, Masaki Inada, Chisato Miyaura

Article Affiliation:

Chiho Matsumoto


We examined the effects ofβ-cryptoxanthin, a typical carotenoid, on inflammatory periodontitis. β-Cryptoxanthin suppressed lipopolysaccharide (LPS)-induced osteoclast formation in co-cultures of bone marrow cells and osteoblasts. In a mouse model of periodontitis, it suppressed bone resorption in the mandibular alveolar bone in vitro and restored alveolar bone loss induced by LPS in vivo. β-Cryptoxanthin might protect against periodontal disease.

Study Type : Animal Study, In Vitro Study

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