Beta-elemene can modulate multiple molecular pathways involved in carcinogenesis. - GreenMedInfo Summary
Multi-Targeting by-Elemene and Its Anticancer Properties: A Good Choice for Oncotherapy and Radiochemotherapy Sensitization.
Nutr Cancer. 2019 Aug 7:1-14. Epub 2019 Aug 7. PMID: 31387393
Several studies have focused on chemical agents, tailored from natural edible products, used to prevent and treat various diseases.β-elemene is a well-known compound derived fromthat possesses a wide spectrum of anticancer properties under preclinical and clinical conditions. Several studies have demonstrated its inhibitory effect both in humans and animals with cancers. Numerousandexperimental models have revealed thatβ-elemene can modulate multiple molecular pathways involved in carcinogenesis. In general, (1) β-elemene itself can inhibit and kill tumor cells through a variety of mechanisms, and (2) can synergistically enhance the effect of radiotherapy and/or chemotherapy, (3) also can regulate autoimmune inthe treatment of tumors. In this article, we critically focused on the available scientific evidence discussing the use of β-elemene in cancer prevention, and its molecular targets and mechanisms of action in different types of cancer. In addition, we have discussed its sources, chemistry, bioavailability, and future research directions.