Article Publish Status: FREE
Abstract Title:

The effects of beta-glucan rich oat bread on serum nitric oxide and vascular endothelial function in patients with hypercholesterolemia.

Abstract Source:

Biomed Res Int. 2014 ;2014:481904. Epub 2014 Jun 12. PMID: 25025057

Abstract Author(s):

Faezeh Tabesh, Hamid Sanei, Mansour Jahangiri, Amir Momenizadeh, Elham Tabesh, Kiana Pourmohammadi, Masoumeh Sadeghi

Article Affiliation:

Faezeh Tabesh


INTRODUCTION: Oats are high in soluble fibers and effective in reducing the risk of cardiovascular diseases (CVD). We assessed the effects of beta-glucan from oat bran on serum nitric oxide (NO) endothelial function in patients with hypercholesterolemia.

METHOD: Sixty hypercholesterolemic patients were randomly divided to receive an experimental bread rich in beta-glucan from oat bran (intervention) or bread rich in wheat fiber (control) for four weeks. All subjects had the same diet for two-week baseline period and hypocaloric diet for four weeks of intervention. Serum NO concentration and flow-mediated dilation (FMD) were determined before and after the experiment.

RESULTS: Mean age of the participants was 51.1± 9.3 years and 65% (n = 39) were female. After intervention, serum NO concentration increased by 50.2 ± 19.8 μmol/lit in the intervention group (P = 0.017), but no change was observed in the control group (17.5 ± 27.5 μmol/lit; P = 0.530). No change of FMD was observed in the intervention(0.48 ± 0.78%; P = 0.546) or in the control group (0.59 ± 0.92%; P = 0.533).

CONCLUSION: Consumption of oat bread for four weeks increases serum NO concentration but has no effect on FMD. Further studies are warranted in this regard.

Study Type : Human Study

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Sayer Ji
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