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Article Publish Status: FREE
Abstract Title:

Betulinic acid in the treatment of tumour diseases: Application and research progress.

Abstract Source:

Biomed Pharmacother. 2021 Oct ;142:111990. Epub 2021 Aug 10. PMID: 34388528

Abstract Author(s):

Wenkai Jiang, Xin Li, Shi Dong, Wence Zhou

Article Affiliation:

Wenkai Jiang

Abstract:

Betulinic acid (BA) is a pentacyclic triterpene compound that can be obtained by separation, chemical synthesis and biotransformation from birch. BA has antitumour activity, and its mechanisms of action mainly include the induction of mitochondrial oxidative stress; the regulation of specificity protein transcription factors, and the inhibition of signal transducer and activator of transcription 3 and nuclear factor-κB signalling pathways. In addition, BA can increase the sensitivity of cancer cells to other chemotherapy drugs. Recent studies have shown that BA plays an anticancer role in several kinds of tumour diseases. In this article, the anticancer mechanism of BA and its application in the treatment of tumour diseases are reviewed.

Study Type : Review

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