Article Publish Status: FREE
Abstract Title:

Antimutagenic action of the triterpene betulinic acid isolated from Scoparia dulcis (Scrophulariaceae).

Abstract Source:

Genet Mol Res. 2015 ;14(3):9745-52. Epub 2015 Aug 19. PMID: 26345907

Abstract Author(s):

P L de Freitas, A C S Dias, V R Moreira, S G Monteiro, S R F Pereira

Article Affiliation:

P L de Freitas


The mutagenic and antimutagenic activities of triterpene betulinic acid {3b-3-hydroxy-lup-20(29)-en-28-oic} isolated from the roots of Scoparia dulcis (Scrophulariaceae) were analyzed using the somatic mutation and recombination test (SMART) in the wings of Drosophila melanogaster. The mutagenic potential of betulinic acid was evaluated at 3 different concentrations (1.64, 3.28, and 6.57 mM). Antimutagenic activity evaluation was performed by co-treatment trials in which the flies received betulinic acid at 3 different concentrations in addition to 10 mM pro-mutagenic urethane. The results demonstrated that betulinic acid was not capable of causing DNA damage. However, the frequency of small single spots, large spots, and twin spots was significantly reduced. In the high bioactivation cross, betulinic acid was significantly active and exerted enhanced antimutagenic activity, possibly as a desmutagen.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antimutagenic Agents : CK(164) : AC(99)

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