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Abstract Title:

Bifidobacterium longum subsp. longum 5Attenuates Signs of Inflammation in a Murine Model of Food Allergy.

Abstract Source:

Probiotics Antimicrob Proteins. 2021 Sep 24. Epub 2021 Sep 24. PMID: 34558015

Abstract Author(s):

Spencer S Santos, Vivian C Miranda, Luísa M Trindade, Valbert N Cardoso, Diego C Reis, Geovanni D Cassali, Jacques R Nicoli, Denise C Cara, Flaviano S Martins

Article Affiliation:

Spencer S Santos

Abstract:

Food allergy is a pathological condition that can lead to hives, swelling, gastrointestinal distress, cardiovascular and respiratory compromise, and even anaphylaxis. The lack of treatment resources emphasizes the necessity for new therapeutic strategies, and in this way, probiotics has been pointed out as an alternative, especially because of its immunomodulatory properties. The goal of this study was to evaluate the probiotic effect of Bifidobacterium longum subsp. longum 5(BL5) in a murine model of ovalbumin (OVA) food allergy, as well as to investigate the effect of the dose and viability of the bacteria on the proposed model. For this purpose, the probiotic effect was assessed by clinical, immunological, and histological parameters in mice treated or not with the BL5and sensitized or not with OVA. Oral administration of BL5prevented weight loss and reduced serum levels of IgE anti-OVA and of sIgA in the intestinal fluid. Also, it reduced the intestinal permeability, proximal jejunum damage, recruitment of eosinophils and neutrophils, and levels of eotaxin-1, CXCL1/KC, IL4, IL5, IL6, IL13, and TNF. Furthermore, the treatment was able to increase the levels of IL10. Investigating different doses administered, the level of 10 CFU showed the best results in terms of protective effect. In addition, the administration of the inactivated bacteria did not present any beneficial effect. Results demonstrate that BL5promotes a systemic immunomodulatory protective effect in a murine model of food allergy that depends on the dose and viability of the bacteria, suggesting its use as probiotic in such disease.

Study Type : Animal Study

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