Abstract Title:

Protective effects of bilberry (Vaccinium myrtillus L.) extract on restraint stress-induced liver damage in mice.

Abstract Source:

J Agric Food Chem. 2008 Sep 10;56(17):7803-7. Epub 2008 Aug 9. PMID: 18690680

Abstract Author(s):

Li Bao, Xin-Sheng Yao, Chin-Chin Yau, Daniel Tsi, Chew-Sern Chia, Hajime Nagai, Hiroshi Kurihara

Abstract:

Full Citation: "Our experiments showed that 18 h restraint stress could induce serious liver damage, with an increase in plasma alanine aminotransferase (ALT) level (107.68 +/- 3.19 U/L vs 18.08 +/- 1.46 U/L). Meanwhile, we observed increased malondialdehyde (MDA) levels and lowered oxygen radical absorbance capacity (ORAC) values in plasma and liver of restraint mice compared with starved mice. Bilberry extract (containing 42.04% anthocyanins) was oral administrated to mice at 50, 100, and 200 mg/(kg x day) for five days, which remarkably decreased plasma ALT level to 17.23 +/- 2.49 U/L at the dose of 200 mg/(kg x day) and thus alleviated stress-induced liver damage. In addition, bilberry extracts increased glutathione (GSH) and vitamin C levels and significantly decreased MDA and nitric oxide (NO) levels in the liver tissues. These results suggest that bilberry extract plays an important role in protecting against restraint stress-induced liver damage by both scavenging free radicals activity and lipid peroxidation inhibitory effect. This study showed the beneficial health effects of bilberry extract through its antioxidative action."

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