n/a
Abstract Title:

Bioassay-Guided Isolation of an Abetiane-Type Diterpenoid fromThat Protects against Concanavalin A-Induced Autoimmune Hepatitis.

Abstract Source:

J Nat Prod. 2021 08 27 ;84(8):2189-2199. Epub 2021 Aug 12. PMID: 34383500

Abstract Author(s):

Yunfang Cao, Xiaosheng Tan, Ali Adhab Al Chnani, Pengkun Li, Zhengyi Shi, Hao Feng, Lingjuan Sun, Qiangbing Xia, Xi Yang, Yulin Duan, Yi Guo, Gang Chen, Changxing Qi, Yonghui Zhang

Article Affiliation:

Yunfang Cao

Abstract:

is a widely used edible Chinese medicinal plant. In the present study, two new abietane-type diterpenoids, abietoquinones A () and B (), were isolated from this plant by an immunosuppressive bioassay-guided isolation procedure. Their structures were elucidated unambiguously by NMR spectroscopic analysis, single-crystal X-ray crystallography, and electronic circular dichroism calculations. Compoundsandbear a cyclohex-2-ene-1,4-dione moiety, which is uncommon among abietane diterpenes. Also, abietoquinone A () suppressed murine splenocyte proliferation and decreased the production of proinflammatory cytokines induced by concanavalin A (Con A) in vitro. In Con A-challenged mice, preinjection withsignificantly ameliorated liver injury. Additionally, abietoquinone A () exhibited inhibitory activities against the proliferation of murine splenocytes and human T cells induced by anti-CD3/anti-CD28 monoclonal antibodies (mAbs).

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.