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Abstract Title:

Biochanin A, a soy isoflavone, diminishes insulin resistance by modulating insulin-signalling pathway in high-fat diet-induced diabetic mice.

Abstract Source:

Arch Physiol Biochem. 2020 Sep 29:1-7. Epub 2020 Sep 29. PMID: 32990040

Abstract Author(s):

Sundaresan Arjunan, Radhiga Thangaiyan, Deivasigamani Balaraman

Article Affiliation:

Sundaresan Arjunan

Abstract:

AIM: The objective of this study was to evaluate the probable mechanism of action of Biochanin A (BCA) on high-fat diet-induced insulin resistance mice.

METHODS: Twenty-four male C57/BL/6J mice were divided into two and fed either control diet or a high fat-high diet (HFD). After 6 weeks, mice were grouped into: Control, Control + BCA, HFD and HFD + BCA ( = 6). Mice were made diabetic by feeding them an HFD.

RESULTS: Body weight, plasma glucose, insulin, leptin levels and HOMA values were significantly lower in the BCA supplemented HFD group when related to the HFD group. Furthermore, BCA supplementation significantly increased Insulin receptor substrate 1 (IRS 1), PI3K, Akt and Glucose transporter type 4 (GLUT-4) protein abundance in skeletal muscle when equated with HFD.

CONCLUSION: This study demonstrates that BCA can improve insulin sensitivity by activating insulin signalling, suggesting that it may possess antidiabetic activities.

Study Type : Animal Study

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Sayer Ji
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