Abstract Title:

demethoxycurcumin Suppresses Migration and Invasion of Human Cervical Cancer HeLa CellsInhibition of NF-ĸB, MMP-2 and -9 Pathways.

Abstract Source:

Anticancer Res. 2018 Jul ;38(7):3989-3997. PMID: 29970522

Abstract Author(s):

Ching-Lung Liao, Yung Lin Chu, Hui-Yi Lin, Cheng-Yen Chen, Ming-Jie Hsu, Kuo-Ching Liu, Kuang-Chi Lai, An-Cheng Huang, Jing-Gung Chung

Article Affiliation:

Ching-Lung Liao


BACKGROUND/AIM: Bisdemethoxycurcumin (BDMC) exhibits biological activities including anticancer and anti-metastasis in human cancer cell lines, but there is no available information to show whether BDMC suppresses cell migration and invasion of human cervical cancer cells.

MATERIALS AND METHODS: Wound-healing, migration, invasion, zymography, and western blotting assays were used to investigate the effects of BDMC on HeLa cells in vitro.

RESULTS: BDMC reduced the total viable cell number in a dose-dependent manner. The wound-healing assay show BDMC suppressed the movement of HeLa cells. Furthermore, the trans-well chamber assays showed that BDMC suppressed the cell migration and invasion. Gelatin zymograph assay showed that BDMC did not inhibit matrix metalloproteinase-2 (MMP-2) and -9 activities in vitro. However, western blotting assay showed that BDMC significantly reduced protein levels of growth factor receptor-bound protein 2 (GRB2), Ras homolog gene family, member A (Rho A), urokinase-type plasminogen activator (uPA), RAS, MMP-2, and N-cadherin but increased those of phosphor-extracellular-signal related kinase (p-ERK1/2), E-cadherin and nuclear factor-ĸB (NF-ĸB) in HeLa cells. Confocal laser microscopy assay was used to further confirm BDMC increased NF-ĸB when compared to controls.

CONCLUSION: BDMC may have potential as a novel anti-metastasis agent for the treatment of human cervical cancer.

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