Abstract Title:

Urinary bisphenol A concentrations in relation to serum thyroid and reproductive hormone levels in men from an infertility clinic.

Abstract Source:

Environ Sci Technol. 2010 Feb 15;44(4):1458-63. PMID: 20030380

Abstract Author(s):

John D Meeker, Antonia M Calafat, Russ Hauser

Article Affiliation:

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, Centers for Disease and Control and Prevention, Atlanta, GA, Department of Environmental Health, Harvard School of Public Health, Boston, MA, and Vincent Memorial Obstetrics and Gynecology Service, Andrology Laboratory and In Vitro Fertilization Unit, Massachusetts General Hospital, Boston, MA.


Human exposure to bisphenol A (BPA) is widespread. Animal studies have demonstrated that BPA can alter endocrine function, but human studies are limited. For the present study, we measured urinary BPA concentrations and serum thyroid and reproductive hormone levels in 167 men recruited through an infertility clinic. BPA was detected in 89% of urine samples with a median (range) of 1.3 (<0.4 - 36.4) ng/mL. In multivariable regression models adjusted for potential confounders, BPA concentrations in urine collected on the same day as a blood sample were inversely associated with serum levels of inhibin B and estradiol:testosterone ratio (E(2):T) and positively associated with follicle-stimulating hormone (FSH) and FSH:inhibin B ratio. Because BPA is metabolized quickly and multiple urine measures may better reflect exposure than a single measure, we also considered among a subset of the men the BPA concentrations in repeated urine samples collected weeks or months following serum sample collection. In these analyses, the effect estimates remained consistent for FSH and E(2):T but were somewhat weakened for inhibin B. In addition, we observed inverse relationships between urinary BPA concentrations and free androgen index (ratio of testosterone to sex hormone binding globulin), estradiol, and thyroid stimulating hormone. Our results suggest that urinary BPA concentrations may be associated with altered hormone levels in men, but these findings need to be substantiated through further research.

Study Type : Human Study

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