Article Publish Status: FREE
Abstract Title:

Bisphenol A in dental sealants and its estrogen like effect.

Abstract Source:

Indian J Endocrinol Metab. 2012 May ;16(3):339-42. PMID: 22629496

Abstract Author(s):

Manu Rathee, Poonam Malik, Jyotirmay Singh

Article Affiliation:

Department of Prosthodontics, Post Graduate Institute of Dental Sciences (PGIDS), Pt. B.D. Sharma University of Health Sciences, Rohtak, India.


Bisphenol A or BPA-based epoxy resins are widely used in the manufacture of commercial products, including dental resins, polycarbonate plastics, and the inner coating of food cans. BPA is a precursor to the resin monomer Bis-GMA. During the manufacturing process of Bis-GMA dental sealants, Bisphenol A (BPA) might be present as an impurity or as a degradation product of Bis-DMA through esterases present in saliva. Leaching of these monomers from resins can occur during the initial setting period and in conjunction with fluid sorption and desorption over time and this chemical leach from dental sealants may be bioactive. Researchers found an estrogenic effect with BPA, Bis-DMA, and Bis-GMA because BPA lacks structural specificity as a natural ligand to the estrogen receptor. It generated considerable concern regarding the safety of dental resin materials. This review focuses on the BPA in dental sealants and its estrogen-like effect.

Study Type : Review
Additional Links
Anti Therapeutic Actions : Dental Sealant Use : CK(1) : AC(0)
Adverse Pharmacological Actions : Estrogenic : CK(65) : AC(22)

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