n/a
Abstract Title:

Bisphenol F-induced neurotoxicity towards zebrafish embryos.

Abstract Source:

Environ Sci Technol. 2019 Nov 8. Epub 2019 Nov 8. PMID: 31702913

Abstract Author(s):

Lilai Yuan, Le Qian, Yu Qian, Jia Liu, Ke Yang, Ying Huang, Chengju Wang, Yingren Li, Xiyan Mu

Article Affiliation:

Lilai Yuan

Abstract:

In this study, the influence of bisphenol F (BPF) toward central neural system (CNS) was assessed using zebrafish embryos. We found that BPF could induce significant neurotoxicity towards zebrafish embryos, including inhibited locomotion, reduced moving distance and CNS cell apoptosis at an effective concentration of 0.0005 mg/L. Immunofluorescence assay showed that both microglia and astrocyte in zebrafish brain were significantly activated by BPF, indicating the existence of neuroinflammatory response. A motor neuron green fluorescence (MnGF) transgenic zebrafish assay showed that BPF significantly inhibited motor neuron development at 72 hpf. RNA-seq data indicated that neuronal developmental processes and cell apoptosis pathways were significantly affected by BPF exposure, which was consistent with the phenotypic results. Chip-Seq assay implied that the transcriptional changes were not mediated by ERα. Additionally, no significant change was found in neurotransmitter levels (5-hydroxytryptamine, dopamine, acetylcholine) or acetylcholinesterase (ache) enzyme activity after BPF exposure, indicating BPF may not affect neurotransmission. In conclusion, BPF could lead to abnormal neural outcomes during zebrafish early life stage through inducing neuroinflammation and CNS cell apoptosis even at environmentally relevant concentrations.

Study Type : Animal Study
Additional Links
Problem Substances : Bisphenol F : CK(2) : AC(1)
Adverse Pharmacological Actions : Neurotoxic : CK(1458) : AC(323)

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.