Abstract Title:

Bisphenol S Interacts with Catalase and Induces Oxidative Stress in Mouse Liver and Renal Cells.

Abstract Source:

J Agric Food Chem. 2016 Aug 10. Epub 2016 Aug 10. PMID: 27508457

Abstract Author(s):

Rui Zhang, Rutao Liu, Wansong Zong

Article Affiliation:

Rui Zhang


Bisphenol S (BPS) is present in multitudinous consumer products and detected in both the food and water. It also has been a main substitute for BPA in food packaging industry. Yet, toxicity of BPS is not fully understood. The present study of the toxicity of BPS was divided into two parts. Firstly, oxidative stress, cell viability, apoptosis level and catalase (CAT) activity in mouse hepatocytes and renal cells were investigated after BPS exposure. After 12 h incubation with BPS, all of these parameters of hepatocytes and renal cells changed more than 15% as the concentration of BPS ranged from 0.1 mM to 1 mM. Secondly, the direct interaction between BPS and CAT on the molecule level was investigated by multiple spectra methods and molecular docking investigations. BPS changed the structure and the activity of CAT through binding to Gly 117 residue on the substrate channel of the enzyme. The main binding forces were hydrogen bond and hydrophobic force.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.