Abstract Title:

Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils.

Abstract Source:

Reprod Toxicol. 2019 Feb 26 ;85:83-92. Epub 2019 Feb 26. PMID: 30822521

Abstract Author(s):

João Paulo Assis Silva, Jordana Gomes Ramos, Mônica Sousa Campos, Danilo da Silva Lima, Pedro Vale de Azevedo Brito, Elizabeth Pereira Mendes, Sebastião Roberto Taboga, Manoel Francisco Biancardi, Paulo César Ghedini, Fernanda Cristina Alcantara Santos

Article Affiliation:

João Paulo Assis Silva


This study evaluated the effects of BPS (40 μg/kg/day, during 28 consecutive days) on the male ventral prostate and female prostate of adult gerbils. For comparative purposes, gerbils were also exposed to BPA under the same experimental conditions. The prostates were submitted to biometric, morphometric, histopathological, immunohistochemical and ultrastructural analyses. The results demonstrated that exposure to both types of bisphenol caused no changes in testosterone or estradiol serum levels. Morphologically, the effects of BPS and BPA on female prostates were similar and included changes in prostatic tissue compartments, glandular hyperplasia, AR and ERα up-regulation and increased cell proliferation. In males, BPS and BPA promoted differential effects, since the prostate presented morphological changes and proliferative disorders that were more pronounced in the BPS group. Therefore, this study demonstrates that BPS caused endocrine disruption in the prostate of male and female gerbils.

Study Type : Animal Study
Additional Links
Problem Substances : Bisphenol S : CK(514) : AC(172)

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