Abstract Title:

Human exposure to Bisphenol A and liver health status: Quantification of urinary and circulating levels by LC-MS/MS.

Abstract Source:

J Pharm Biomed Anal. 2017 Jun 5 ;140:105-112. Epub 2017 Mar 10. PMID: 28346880

Abstract Author(s):

Carla Nicolucci, Sonia Errico, Alessandro Federico, Marcello Dallio, Carmelina Loguercio, Nadia Diano

Article Affiliation:

Carla Nicolucci


A selective and highly sensitive analytical methodology for determination of Bisphenol A in human plasma was developed and validated. The method was based on selective liquid/solid extraction, combined with liquid chromatography-electrospray ionization tandem mass spectrometry in the multiple reaction monitoring mode and negative ionization. The linearity of the detector response was verified in human plasma over the concentration range 0.100-200ngmL(-1). The detection limit was 0.03ngmL(-1) and the quantification limit was 0.100ngmL(-1). The analytical features of the proposed in-house validated method were satisfactory: precision was<10% and recoveries were around 84-104%. The matrix effect was studied and compensated using deuterated labeled standard. The applicability of the proposed method was demonstrated analyzing human plasma samples from individuals affected by non-alcoholic fatty liver disease. Bisphenol A was detected above the detection limit in all samples. The data show a persistence of unconjugated Bisphenol A levels in plasma and indicate a chronic Bisphenol A exposure of the target organ, suggesting an association between liver health status and Bisphenol A exposure. The results from our study are valuable for further investigation with large sample size and longitudinal study designs, necessary to confirm the observed association.

Study Type : Human In Vitro, Human Study

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