Article Publish Status: FREE
Abstract Title:

Kaempferia parviflora extract increases whole-body energy expenditure in humans: roles of brown adipose tissue.

Abstract Source:

J Nutr Sci Vitaminol (Tokyo). 2015 ;61(1):79-83. PMID: 25994142

Abstract Author(s):

Mami Matsushita, Takeshi Yoneshiro, Sayuri Aita, Tomoyasu Kamiya, Nobutaka Kusaba, Kazuya Yamaguchi, Kinya Takagaki, Toshimitsu Kameya, Hiroki Sugie, Masayuki Saito

Article Affiliation:

Mami Matsushita


Kaempferia parviflora extract (KP) has been reported to have a preventive effect on obesity in mice, probably by increasing energy expenditure (EE). The aims of the current study were to examine the acute effects of KP ingestion on whole-body EE in humans and to analyze its relation to the activity of brown adipose tissue (BAT), a site of non-shivering thermogenesis. After an oral ingestion of an ethanol extract of KP, EE increased significantly, showing a maximal increase of 229±69 kJ/d at 60 min, while it did not change after placebo ingestion. To evaluate BAT activity, the subjects underwent fluorodeoxyglucose-positron emission tomography, and divided into two groups with high- and low-BAT activities. A similar and greater response of EE to KP ingestion was observed inthe high-BAT group (351±50 kJ/d at 60 min), but not in the low activity group. Placebo ingestion did not cause any significant EE change in either group. These results indicate that a single oral ingestion of the KP extract can potentially increase whole-body EE probably through the activation of BAT in healthy men, and may be useful as an anti-obesity regimen.

Study Type : Human Study

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