Article Publish Status: FREE
Abstract Title:

Black ginger extract increases physical fitness performance and muscular endurance by improving inflammation and energy metabolism.

Abstract Source:

Heliyon. 2016 May ;2(5):e00115. Epub 2016 May 24. PMID: 27441286

Abstract Author(s):

Kazuya Toda, Shoketsu Hitoe, Shogo Takeda, Hiroshi Shimoda

Article Affiliation:

Kazuya Toda


We previously reported that polymethoxyflavones (PMFs) in black ginger (Kaempferia parviflora) extract (KPE) increased energy production by activating AMP-activated protein kinase (AMPK) in C2C12 myoblasts. We herein evaluated the effects of KPE on physical fitness performance and muscular endurance in mice. Male mice were orally administered KPE for 4 weeks, and then forced swimming test, open-field test, inclined plane test, and wire hanging test were performed. KPE significantly increased the swimming time, motility after swimming, and grip strength. IL-6 and TNF-α mRNA expression levels were decreased in the soleus muscle, whereas peroxisome proliferator-activated receptor γ coactivator (PGC)-1α and glycogen synthase mRNA expression levels, mitochondrial number, and glycogen content were increased. These results were in agreement with those obtained forKPE and PMFs in C2C12. Therefore, the activation of AMPK by PMFs may be one of the mechanisms by which KPE improves physical fitness performance and muscular endurance.

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