Abstract Title:

Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum.

Abstract Source:

Molecules. 2010;15(4):2398-404. Epub 2010 Apr 5. PMID: 20428051

Abstract Author(s):

Gwendoline Cheng Lian Ee, Chyi Meei Lim, Mawardi Rahmani, Khozirah Shaari, Choon Fah Joseph Bong

Article Affiliation:

Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia. [email protected]


Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.

Study Type : In Vitro Study

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