Abstract Title:

Antibacterial constituents from the berries of Piper nigrum.

Abstract Source:

Phytomedicine. 2004 Nov;11(7-8):697-700. PMID: 15636188

Abstract Author(s):

S Venkat Reddy, Pullela V Srinivas, B Praveen, K Hara Kishore, B China Raju, U Suryanarayana Murthy, J Madhusudana Rao

Article Affiliation:

Natural Product Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India.


Piper nigrum finds an extensive application in antibacterial preparations belonging to Ayurvedic system of medicine. A bioguided extraction and fractionation of the petroleum ether extract of the berries of P. nigrum afforded 2E, 4E, 8Z-N-isobutyleicosatrienamide (1), pellitorine (2), trachyone (3), pergumidiene (4) and isopiperolein B (5). Pergumidiene and trachyone are isolated for the first time from P. nigrum. All the isolated compounds were active against Bacillus subtilis, Bacillus sphaericus, and Staphylococcus aureus amongst Gram + ve bacteria, and Klebsiella aerogenes and Chromobacterium violaceum among Gram -ve bacterial strains.

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