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Article Publish Status: FREE
Abstract Title:

Black phosphorus conjugation of chemotherapeutic ginsenoside Rg3: enhancing targeted multimodal nanotheranostics against lung cancer metastasis.

Abstract Source:

Drug Deliv. 2021 Dec ;28(1):1748-1758. PMID: 34463184

Abstract Author(s):

Jie Xiong, Hongmei Yuan, Hongge Wu, Jing Cheng, Shengli Yang, Ting Hu

Article Affiliation:

Jie Xiong

Abstract:

It is a significant challenge in lung cancer chemophotothermal (CPT) therapy to develop multifunctional theranostic nanoagent (MTN) for precise targeting and successful tumor treatments, especially for lung metastasis. To overcome this problem, we effectively design and construct multifunctional black phosphorus (BP) nanoagents, BPs/[email protected] BPs quantum dots (BPsQDs) are co-loaded onto poly(lactic-co-glycolic acid) (PLGA) with subsequent conjugations of a cancer therapeutic compound, ginsenoside Rg3 (G-Rg3), in this composite nanoagent. Thedelivery findings suggest that BPs/[email protected] has an excellent affinity for primary tumors and metastatic lung tumors. Furthermore, when paired with near-light irradiation, BPs/[email protected] shows superior controllable CPT therapy synergetic therapeutics, significantly increasing photothermal tumor ablation effectiveness. Mechanistically, heating causes rapid G-Rg3 release from the non-complex, and thermal therapy induces apoptosis, culminating in the reduction of lung cancer metastasis. Additionally,andfindings support the biocompatibility of BPs/[email protected] This thesis identifies a versatile BPs-based MTN for lung cancer metastasis control.

Study Type : Animal Study

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