Blueberry supplementation in midlife for dementia risk reduction. - GreenMedInfo Summary
Blueberry Supplementation in Midlife for Dementia Risk Reduction.
Nutrients. 2022 Apr 13 ;14(8). Epub 2022 Apr 13. PMID: 35458181
Robert Krikorian
Late-life dementia typically develops over a period of many years beginning in midlife. Prevalence of metabolic disturbance also accelerates in middle age and is a prominent risk factor for dementia. Preliminary studies indicate that blueberry supplementation can improve cognitive performance and influence metabolism and brain function and therefore may have a role in early intervention to prevent neurodegeneration. In a randomized controlled trial, we investigated the effects of daily blueberry supplementation in a middle-aged sample of insulin-resistant participants with elevated risk for future dementia. We enrolled overweight men and women, aged 50 to 65 years, with subjective cognitive decline (SCD) and performed pre- and post-intervention assessments of cognition and metabolism and exploratory measures of peripheral mitochondrial function. We observed improved performances for the blueberry group on measures of lexical access,= 0.003, and memory interference,= 0.04, and blueberry-treated participants reported reduced memory encoding difficulty in daily life activities,= 0.03. The blueberry-treated group also exhibited correction of peripheral hyperinsulinemia,= 0.04, and a modest trend for increased mitochondrial uncoupling,= 0.11. The cognitive findings indicated improved executive ability in this middle-aged sample. In addition, the changes in metabolic and bioenergetic measures imply potential mechanistic factors associated with anthocyanin and proanthocyanidin actions. The demonstration of these benefits in middle-aged individuals with insulin resistance and SCD suggests that ongoing blueberry supplementation may contribute to protection against cognitive decline when implemented early in at-risk individuals.