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Article Publish Status: FREE
Abstract Title:

Boswellic Acids Show In Vitro Activity against.

Abstract Source:

Molecules. 2021 Jun 15 ;26(12). Epub 2021 Jun 15. PMID: 34203815

Abstract Author(s):

Hippolyt L Greve, Marcel Kaiser, Pascal Mäser, Thomas J Schmidt

Article Affiliation:

Hippolyt L Greve

Abstract:

In continuation of our search for leads from medicinal plants against protozoal pathogens, we detected antileishmanial activity in polar fractions of a dichloromethane extract fromresin. 11-keto-β-boswellic acid (KBA) could be isolated from these fractions and was tested in vitro againstaxenic amastigotes along with five further boswellic acid derivatives. 3--acetyl-11-keto-β-boswellic acid (AKBA) showed the strongest activity with an ICvalue of 0.88µM against axenic amastigotes but was inactive against intracellular amastigotes in murine macrophages.

Study Type : In Vitro Study

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